JuniperPublishers-Academic Journal of Pediatrics Neonatology

Juniper Publishers - Journal of Pediatrics Abstract Congenital hypothyroidism (CH) is the commonest cause of preventable developmental delay with an incidence of 1/3500-4500 newborns. The incidence of symptomatic cases has decreased dramatically in the developed countries with the advent of newborn screening. However, much work still needs to be done in the developing world in improving awareness and devising newborn screening strategies etc. In this article, we discuss the diagnosis and management of congenital hypothyroidism. Keywords: Red blood cell transfusion; Malondialdehyde; Ferritin; Preterm Abbreviations: CH: Congenital Hypothyroidism; DHG: Dyshormonogenesis; TSH: Thyroid Stimulating Hormone; T4: Thyroxine; TBG: Thyroid Binding Globulin; TS: Thyroid Scintigraphy; TRB-Ab: Thyroid Receptor Blocking Antibody; Introduction Congenital hypothyroidism (CH) is the commonest cause of preventable developmental delay with an i...

Juniper Publishers - Journal of Pediatrics Abstract Aim: Preterm infants commonly receive at least one packed red blood cell transfusion during their stay in the neonatal intensive care unit and even though the complications related to prematurity are multifactorial, especially bronchopulmonary dysplasia, necrotizing enterocolitis and intraventricular hemorrhage have been shown to be independently related with red blood cell transfusions. This study aims to determine the extent of lipid peroxidation in preterm babies after multiple transfusions, and to figure out acut-off value of ferritin to start or withhold iron prophylaxis in transfused babies. Methods: Serum malondialdehyde and ferritin levels of 23 preterm babies (born earlier than 35th gestational week) were measured and the relation between total number of red blood cell transfusions, malondialdehyde and ferritin levels were assessed. Results: The relations between the transfusion numbers and ferriti...