Magnesium Sulfate for Fetal Neuroprotection: Correlation between Maternal and Infant Serum Magnesium Concentrations-Juniper Publishers
Juniper Publishers - Journal of Pediatrics Abstract Background: Pregnant women at risk for preterm labor are commonly treated with magnesium sulfate (MgSO4) for fetal neuroprotection. Randomized controlled studies have shown that this treatment is associated with decreased risk of cerebral palsy. Nevertheless, the optimal MgSO4 dose for neuro protection has not been determined. Moreover, some studies suggest a potential toxic effect associated with high MgSO4 treatment dose and that elevated serum infant Mg concentrations (iMgC) may also be associated with an increased risk for various morbidities and mortality. Objective: To determine the correlation between maternal and infant serum Mg concentration among preterm infants exposed to MgSO4 for neuroprotection. Finding a correlation may contribute to decision-making regarding continuation or discontinuation of maternal treatment prior to delivery. Study Design: A total of 60 infants born at <32 weeks gesta...